產品概述
規格
2*96時間
反應性
人類
樣品類型
Serum/Plasma/Cell Culture Supernatant
Reaction Time
3 hours and 15 分分鐘
檢測範圍
1.56 – 100 的/毫升
靈敏度
0.8 的/毫升
應用
酵素連結免疫吸附試驗
儲存條件
2-8℃
保質期
6 月
單元
盒子
背景
Immunoglobulin G (免疫球蛋白G) is synthesized and secreted by B cells, accounting for 75% of the total immunoglobulin content in the serum, making it the most abundant antibody type in the peripheral circulation. IgG has four subclasses: IgG1, IgG2, IgG3, and IgG4. IgG4 is the least abundant subclass in serum, accounting for 4% of total IgG. Its concentration in the body ranges from 0.35 到 0.51 毫克/毫升, although it varies among individuals. In healthy individuals, IgG4 concentrations can range from 10ug/ml to 1.4 毫克/毫升. The homology between the heavy chains of IgG4 and the other three IgG subclasses exceeds 95%. Many cytokines are involved in promoting the production of IgG4, and these cytokines are similar to those involved in promoting IgE production, such as IL-4, IL-5, IL-6, IL-7, IL-9, and IL-13. 另外, IL-10 and IL-12 are also involved in promoting IgG4 production. Elevated levels of IgG4 in the body lead to a series of inflammatory diseases collectively known as IgG4-related diseases, including sialadenitis, pancreatitis, cholangitis, aortitis, thyroiditis, ETC.
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