Descripción del producto
Especificaciones
2*96t
Reactivity
Human
Tipo de ejemplo
Serum/Plasma/Cell Culture Supernatant
Reaction Time
3 hours and 15 minutos
Detection Range
1.56 – 100 de/ml
Sensibilidad
0.8 de/ml
Solicitud
ELISA
Condiciones de almacenaje
2-8°C
Duración
6 meses
Unidad
Caja
Background
Immunoglobulin G (IgG) is synthesized and secreted by B cells, contabilidad de 75% of the total immunoglobulin content in the serum, making it the most abundant antibody type in the peripheral circulation. IgG has four subclasses: IgG1, IgG2, IgG3, and IgG4. IgG4 is the least abundant subclass in serum, contabilidad de 4% of total IgG. Its concentration in the body ranges from 0.35 a 0.51 mg/ml, although it varies among individuals. In healthy individuals, IgG4 concentrations can range from 10ug/ml to 1.4 mg/ml. The homology between the heavy chains of IgG4 and the other three IgG subclasses exceeds 95%. Many cytokines are involved in promoting the production of IgG4, and these cytokines are similar to those involved in promoting IgE production, such as IL-4, IL-5, IL-6, IL-7, IL-9, and IL-13. Además, IL-10 and IL-12 are also involved in promoting IgG4 production. Elevated levels of IgG4 in the body lead to a series of inflammatory diseases collectively known as IgG4-related diseases, including sialadenitis, pancreatitis, cholangitis, aortitis, thyroiditis, etc..
Reseñas
Aún no hay reseñas.