仕様
- 100mg Powder
| 商品情報 | |
|---|---|
| CAS | 1119-34-2 |
| Chinese Name | L-精氨酸盐酸盐 |
| 英語名 | L-Arginine Hydrochloride |
| 同義語 |
|
| 分子式 | C6H14N4O2·HCl |
| 分子量 | 210.66 |
| 仕様 | 10mM*1mL in Water; 100mg |
| 溶解性 | Soluble in Water ≥10mg/mL |
| 保管条件 | 粉: 2-8℃, 2 年; 溶液中: -20℃, 6 月; -80℃, 1 年 |
| 純度 | HPLC≥98% |
| 外観 | White to off-white Solid |
| ユニット | ボトル |
| EC | EINECS 214-275-1 |
| MDL | MFCD00064550 |
| SMILES | NC@@HC(○)=O.[H]Cl |
| InChIKey | KWTQSFXGGICVPE-WCCKRBBISA-N |
| InChI | InChI=1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1 |
| PubChem CID | 66250 |
| ターゲット | Others |
| Pathway | Others |
| Background Information | Reported to be an effective vasodilator used to induce experimental acute pancreatitis. |
| Biological Activity | L-Arginine HCl (L-Arg) is a nitrogen donor for nitric oxide synthesis, acting as an effective vasodilator, often deficient in sickle cell anemia [1-2]. |
| In Vitro | Supplementation of L-Arginine (0.3 mM, 30 分) increases NO concentration twofold in bovine aortic endothelial cells with an LDL concentration of 60-130 mg cholesterol/dL. In conditions with low LDL, L-Arginine (0.3 mM, 30 分) does not increase NO peak concentration or O2- levels. Pre-treatment with L-Arginine reduces O2- production by 50% when incubated with n-LDL above 40mg cholesterol/dL and completely inhibits O2- production from oxidized LDL doses [1]. |
| In Vivo | In rabbit limbs with ischemia/reperfusion injury, L-Arginine (4 mg/kg/min for 1 時間) reduces superoxide production by cNOS, increases NO accumulation, prevents microvascular contraction, and significantly reduces muscle edema [2]. |
| 参考文献 | [1]. Vergnani L, 他. Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of L-arginine availability. Circulation. 2000 Mar 21;101(11):1261-6.
[2]. Huk I, 他. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation. 1997 Jul 15;96(2):667-75. |
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