| 属性 | 詳細 |
|---|---|
| 猫 | K108942P |
| 製品名 | Anti-ALPP/ALPG/ALPI antibody |
| Source | Rabbit |
| アイソタイプ | IgG |
| Species reactivity | 人間, ねずみ |
| Swiss Prot | P05187/P10696/P09923 |
| 遺伝子ID | 250/251/248 |
| Calculated MW | 57/58kDa |
| Observed MW | 68kDa |
| 精製 | アフィニティ精製 |
| Tested applications | WB, IHC |
| 推奨希釈 | WB 1:2000-5000, IHC 1:50-200 |
| WB Positive sample | MCF7 |
| IHC Positive sample | Human testis cancer |
| 細胞内の場所 | 細胞質 |
| 免疫原 | A synthetic peptide of Human ALPP/ALPG/ALPI |
| ストレージ | Shipped at 4 ℃. Upon delivery, aliquot and store at -20 ℃ |
背景:
ALPP (Alkaline phosphatase placental type; also SEAP, PALP-1 and ALP) is a 66-68 kDa glycoprotein member of the alkaline phosphatase family of molecules. It is principally expressed by 2nd and 3rd trimester synctiotrophoblasts and tumor cells, and represents one of four alkaline phosphatase isozymes. Experimentally, it cleaves phosphate monoesters into alcohol and phosphate. Human ALPP is synthesized as a 535 amino acid (aa) preproprecursor. It contains a 22 aa signal sequence, ある 484 mature region (aa 23-506), そして 29 aa C-terminal propeptide that is cleaved to generate a GPI linkage at Asp506. The ALPP gene is highly allelic and may generate three potential splice variants that involve the signal sequence. The ALPP enzyme utilizes one Mg and two Zn ions, and functions as either a homodimer, or a heterodimer with the related Intestinal (ALPI) and Germ cell (GCAP) family members on the cell surface. ALPP is reported to oligomerize under certain conditions. Over aa 23-506, human ALPP shares 96% そして 77% aa identity with chimpazeee ALPP and mouse embryonic-type alkaline phosphatase, それぞれ. It also shares 88% そして 98% aa identity with IAP and GCAP, それぞれ. Over aa 23-506, human ALPP shares 86% aa identity with human ALPI.
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