| Atribut | Detail |
|---|---|
| Spesifikasi | 50jalan / 100jalan |
| Conjugation | Unconjugation |
| Host | Rabbit |
| Clonality | Polyclonal Antibody |
| Gene symbol | GET3 |
| Immunogen | Recombinant protein of human GET3 |
| Sinonim | ASNA1; ARSA-I; ARSA1; ASNA-I; GET3; TRC40; hASNA-I |
| Isotype | IgG |
| Gene ID | 439 |
| Swiss Port | O43681 |
| Berat molekul | 39kDa |
| Pemurnian | Affinity purification |
| Reaktivitas | Manusia, Mouse, Rat |
| Aplikasi | IHC |
| Recommended dilution | IHC 1:50-200 |
| Subcellular location | Sitoplasma, Inti |
| Penyimpanan | Simpan pada suhu -20°C. Avoid freeze/thaw cycles. |
| Background | ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. |
Solarbio Anti-GET3 Polyclonal Antibody
Dari$175.00
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Deskripsi
Informasi Tambahan
| Ukuran | 50jalan, 100jalan |
|---|
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